Ruiqiang Ye

Personal Profile

Education

2009-2014 Ph.D. in Biochemistry and Molecular Biology, Zhejiang University (ZJU), China.

2010-2012 Visiting graduate student  National Institute of Biological Sciences, Beijing (NIBS), China

2012-2014 Visiting graduate student  Tsinghua University (THU), China

2005-2009 B.S. in Biology         Wuhan University (WHU), China

Research Experience

07/2022-Present Principle Investigator  CAS Centre for Excellence in Molecular Plant Sciences, China

2020-2022 Research Associate         Department of Molecular Biology, Massachusetts General Hospital

                            Department of Genetics, Harvard Medical School, United States

2015-2020 Research Fellow           Department of Molecular Biology, Massachusetts General Hospital

                            Department of Genetics, Harvard Medical School, United States

Research Work

Carbon and Nitrogen are ancient and fundamental nutrient signals to regulate and sustain life by integrating with other intrinsic and extrinsic stimuli. Emerging evidence indicates that the evolutionarily conserved target-of-rapamycin (TOR) kinase is a master integrator of nutrient and energy signalling in both plants and animals. My overall research interest is on how plants sense nutrients and transmit the signals to chromatin to regulate their metabolism, growth, and development. Specifically, my group will use Arabidopsis thaliana and rice as model plants to address: How carbon and nitrogen availability are sensed and transduced to TOR? How TOR signaling regulate metabolism, growth and development in response to diverse nutrient and stress stimuli? Whether and how nutrient signaling could be manipulated to enhance anabolic processes and improve crop yield? These studies are of great significance for solving problems related to efficient utilization of carbon and nitrogen by plants and enhancing carbon assimilation efficiency.

Main Achievements

 

Publications

1. Cheng Y-J^#, Wang, J-W, Ye, R.* (2023) Histone dynamics responding to internal and external cues underlying plant development. Plant Physiology In press

 

2. Ye, R. # *, Lin, Z., Liu, K-H, Sheen, J., Chen, S.* (2023) Dynamic Proximity Tagging in Living Plant Cells with Pupylation-Based Interaction Tagging. Methods in Molecular Biology 2690, 137-147.

 

3. Ye, R. # *, Wang, M., Du, H., Chhajed, S., Kol, J., Liu, K., Shin, J., Wu, Y., Shi, L., Xu, L., Chen, S., Zhang, Y., Sheen, J.* (2022) Glucose-Driven TOR-FIE-PRC2 signalling controls plant development. Nature 609, 986–993

 

4. Ye, R. #, Chen, Z. ^#, Bi, L. ^#, Rowley, MJ, Xia, N., Chai J, Li, Y., He, XJ., Wierzbicki, A.T.,and Qi, Y.* (2016). A Dicer-Independent Route for Biogenesis of siRNAs that Direct DNA Methylation in Arabidopsis. Mol Cell 61, 222-35 (Cover story) (*Co-first authors)

 

5. Wu, J. ^#, Yang, Z. ^#, Zheng, L., Wang Y., Ye, R., Ji, Y., Zhao, S., Ji, S., Xu, L.,Zheng, H., Jin, L., Wu, X., Hong, W., Wei, C., Zhou, Yi. Cao,X., Xie, L., Wu, Z., Qi,Y. *, and Li Y.* (2015). Virus-Inducible Argonaute18 Confers Broad-Spectrum Virus Resistance in rice by sequestering a host microRNA. Elife 17; 4. doi: 10.7554/eLife.05733. (*Co-first authors; #co-corresponding authors)

 

6. Ye, R. #, Wang, W. ^#, Iki, T., Liu, C., Wu, Y., Ishikawa, M., Zhou, X., and Qi, Y.* (2012). Cytoplasmic Assembly and Selective Nuclear Import of Arabidopsis ARGONAUTE4/siRNA Complexes. Mol Cell 46, 859-870 (Highlighted in Mol Cell and Faculty of 1000)

 

7. Wang, W. ^#, Ye, R. #, Xin, Y., Fang, X., Li, C., Shi, H., Zhou, X., and Qi, Y.* (2011). An importin beta protein negatively regulates MicroRNA activity in Arabidopsis. Plant Cell 23, 3565-3576. (Cover story)