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Principal Investigator
Researcher
Email:jwwang@sippe.ac.cn
Personal Web: http://wanglab.sippe.ac.cn/


Research Direction

Plant aging and regeneration 


Research Unit

National Key Laboratory of Plant Molecular Genetics

Jiawei Wang

Personal Profile

Education

1999-2005, Ph D. in Plant Molecular Genetics, Institute of Plant Physiology and Ecology (SIPPE), Shanghai Institutes for Biological Sciences (SIBS) Chinese Academy of Sciences (CAS)

1995-1999, Bachelor of Philosophy, Life Science College of Life Sciences, Shanghai Jiaotong University

 

Professional Experience

2014-present, Joint Professor, Shanghai Tech University

2011-present, Principal investigator, National Key Lab of Plant Molecular Genetics (NKLPMG), SIPPE, CAS

2005-2011, Postdoc Max Planck Institute for Developmental Biology, Department of Molecular Biology, Tuebingen, Germany


Research Work

Using genetics, reverse genetics, single-cell RNA sequencing, and cell lineage tracing techniques, our lab employs the model annual plant Arabidopsis thaliana and its perennial relatives in the Brassicaceae to address the following scientific questions: 1) The molecular mechanisms underlying the irreversibility of plant maturation and aging; 2) The genetic basis of natural variations in plant life-cycle strategies; 3) The molecular mechanisms behind the longevity and regenerative capacity of plants.


Main Achievements

1. Molecular mechanisms underlying plant maturation and aging

Key articles:

1) Gao J#, Zhang K#, Cheng YJ#, Shang GD, Wang FX, Wu LY, Xu ZG, Mai YX, Zhao XY, Zhai D, Lian H, and Wang JW*. (2022). A robust mechanism for reset of juvenility during each generation in Arabidopsis. Nat Plants. 8(3): 257-268.

2) Cheng YJ, Shang GD, Xu ZG, Yu S, Wu LY, Zhai D, Tian SL, Gao J, Wang L, and Wang JW*. (2021). Cell division in the shoot apical meristem is a trigger for miR156 decline and vegetative phase transition in Arabidopsis. Proc Natl Acad Sci USA. 118(46): e2115667118.

3) Yu S, Cao L, Zhou CM, Zhang TQ, Lian H, Sun Y, Wu JQ, Huang JR, Wang GD, and Wang JW*. (2013). Sugar is an endogenous cue for juvenile-to-adult phase transition in plants. eLife. 2: e00269. (Highlighted by eLife)

4) Lian H, Wang L, Ma N, Zhou CM, Han L, Zhang TQ, and Wang JW*. (2021). Redundant and specific roles of individual MIR172 coding genes in plant development. PLoS Biol. 19(2): e3001044. (PRIMER by PLoS Biol)

5) Wang L#, Zhou CM#, Mai YX, Li LZ, Gao J, Shang GD, Lian H, Han L, Zhang TQ, Tang HB, Ren H, Wang FX, Wu LY, Liu XL, Wang CS, Chen EW, Zhang XN, Liu C, and Wang JW*. (2019). A spatiotemporally regulated transcriptional complex underlies heteroblastic development of leaf hairs in Arabidopsis thaliana. EMBO J. 38(8): 100063.

6) Tang HB, Wang J, Wang L, Shang GD, Xu ZG, Mai YX, Liu YT, Zhang TQ, and Wang JW*. (2023). Anisotropic cell growth at the leaf base promotes age-related changes in leaf shape in Arabidopsis thaliana. Plant Cell. 35(5): 1386-1407.

7) Rubio-Somoza I, Zhou CM, Confraria A, Martinho C, Born P, Baena-Gonzalez E, Wang JW*, and Weigel D*. (2014). Temporal control of leaf complexity by miRNA-regulated licensing of protein complexes. Curr Biol. 24(22): 2714-2719.

8) Yu S#, Galvao V#, Zhang YC, Horrer D, Zhang TQ, Hao YH, Feng YQ, Wang S, Schmid M, and Wang JW*. (2012). Gibberellin regulates Arabidopsis floral transition through miR156-targeted SQUAMOSA PROMOTER BINDING-LIKE transcription factors. Plant Cell. 24(8): 3320-3332.

9) Gou JY, Felipes FF, Liu CJ, Weigel D, and Wang JW*. (2011). Negative Regulation of anthocyanin biosynthesis in Arabidopsis by a miR156-targeted SPL transcription factor. Plant Cell. 23(4): 1512-1522.

 

2. Molecular basis of longevity and perenniality in the Brassicaceae

Key articles:

1) Zhai D#, Zhang LY#, Li LZ#, Xu ZG#, Liu XL, Shang GD, Zhao B, Gao J, Wang FX, and Wang JW*. (2024). Reciprocal conversion between annual and polycarpic perennial flowering behavior in the Brassicaceae. Cell. 187(13): 3319-3337. (Previewed by Cell)

2) Zhou CM, Zhang TQ, Wang X, Yu S, Lian H, Tang H, Feng ZY, Zozomova-Lihova J, and Wang JW*. (2013). Molecular basis of age-dependent vernalization in Cardamine flexuosa. Science. 340(6136): 1097-1100.

3) Li LZ, Xu ZG, Chang TG, Wang L, Kang H, Zhai D, Zhang LY, Zhang P, Liu H, Zhu XG, and Wang JW*. (2023). Common evolutionary trajectory of short life-cycle in Brassicaceae ruderal weeds. Nat Commun. 14: 290.

 

3. Single-cell analysis of plant meristems

Key articles:

1) Zhang TQ, Chen Y, and Wang JW*. (2021). A single-cell analysis of the Arabidopsis vegetative shoot apex. Dev Cell. 56(7): 1056-1074.

2) Wang L, Wan MC, Liao RY, Xu J, Xu ZG, Xue HC, Mai YX, and Wang JW*. (2023). The maturation and aging trajectory of Marchantia polymorpha at single-cell resolution. Dev Cell. 58(15): 1429-1444. (Cover story)

3) Zhang TQ*, Chen Y, Liu Y, and Wang JW*. (2021). Single-cell transcriptome atlas and chromatin accessibility landscape reveal differentiation trajectories in the rice root. Nat Commun. 12: 2053.

4) Zhang TQ#, Xu ZG#, Shang GD, and Wang JW*. (2019). A single-cell RNA sequencing profiles the developmental landscape of Arabidopsis root. Mol Plant. 12(5): 648-660. (Best of Mol Plant 2019)

 

4. Molecular basis of plant regeneration

Key articles:

1) Wu LY#, Shang GD#, Wang FX, Gao J, Wan MC, Xu ZG, and Wang JW*. (2022). Dynamic chromatin state profiling reveals regulatory roles of auxin and cytokinin in shoot regeneration. Dev Cell. 57(4): 526-542.

2) Wang FX#, Shang GD#, Wu LY, Xu ZG, Zhao XY, and Wang JW*. (2020). Chromatin accessibility dynamics and a hierarchical structure of transcriptional regulatory network for plant somatic embryogenesis. Dev Cell. 54(6): 742-757. (Previewed by Dev Cell; Highlighted by Mol Plant)

3) Ye BB, Shang GD, Pan Y, Xu ZG, Zhou CM, Mao YB, Bao N, Sun L, Xu T, and Wang JW*. (2020). AP2/ERF transcription factors integrate age and wound signals for root regeneration. Plant Cell. 32(1): 226-241.

4) Zhang TQ, Lian H, Zhou CM, Xu L, Jiao YL, and Wang JW*. (2017). A two-step model for de novo activation of WUSCHEL during plant shoot regeneration. Plant Cell. 29(5): 1073-1087. (Highlighted by Trends Plant Sci)

5) Zhang TQ, Lian H, Tang H, Dolezal K, Zhou CM, Yu S, Chen JH, Chen Q, Liu H, Ljung K, and Wang JW*. (2015). An intrinsic microRNA timer regulates progressive decline in shoot regenerative capacity in plants. Plant Cell. 27(2): 349-360.

6) Zhou CM#, Li JX#, Zhang TQ, Xu ZG, Ma ML, Zhang P*, and Wang JW*. (2024). The structure of B-ARR reveals the molecular basis of transcriptional activation by cytokinin. Proc Natl Acad Sci USA. 121(3): e2319335121.


Publications

1. Zhai D#, Zhang LY#, Li LZ#, Xu ZG#, Liu XL, Shang GD, Zhao B, Gao J, Wang FX, and Wang JW*. (2024). Reciprocal conversion between annual and polycarpic perennial flowering behavior in the Brassicaceae. Cell. 187(13): 3319-3337.


2. Chen C*, Hu Y*, Ikeuchi M*, Jiao Y*, Prasad K*, Su YH*, Xiao J*, Xu L*, Yang W*, Zhao Z*, Zhou W*, Zhou Y*, Gao J, and Wang, JW*. (2024). Plant regeneration in the new era: from molecular mechanisms to biotechnology applications. SCI CHINA Life Sci. 67(7): 1338-1367.

 

3. Zhou CM#, Li JX#, Zhang TQ, Xu ZG, Ma ML, Zhang P*, and Wang JW*. (2024). The structure of B-ARR reveals the molecular basis of transcriptional activation by cytokinin. Proc Natl Acad Sci USA. 121(3): e2319335121.

 

4. Maple R#, Zhu, P#, Hepworth J, Wang JW*, and Dean C*. (2024). Flowering time: from physiology, through genetics to mechanism. Plant Physiol. 195(1): 190-212.

 

5. Cheng YJ, Wang JW*, and Ye R*. (2024). Histone dynamics responding to internal and external cues underlying plant development. Plant Physiol. 194(4): 1980-1997.

 

6. Zhao B and Wang JW*. (2024). Perenniality: from model plants to applications in agriculture. Mol Plant. 17(1): 141-157.

 

7. Wang L, Wan MC, Liao RY, Xu J, Xu ZG, Xue HC, Mai YX, and Wang JW*. (2023). The maturation and aging trajectory of Marchantia polymorpha at single-cell resolution. Dev Cell. 58(15): 1429-1444.

 

8. Liao RY and Wang JW*. (2023). Analysis of meristems and plant regeneration at single-cell resolution. Curr Opin Plant Biol. 74: 102378.

 

9. Li LZ, Chang TG, Kang H, Zhu XG, and Wang JW*. (2023). Simulating evolution trajectory of ruderal weeds by computational modeling. Plant Physiol. 193(2): 923-926.

 

10. Li LZ, Xu ZG, Chang TG, Wang L, Kang H, Zhai D, Zhang LY, Zhang P, Liu H, Zhu XG, and Wang JW*. (2023). Common evolutionary trajectory of short life-cycle in Brassicaceae ruderal weeds. Nat Commun. 14: 290.

 

11. Tang HB, Wang J, Wang L, Shang GD, Xu ZG, Mai YX, Liu YT, Zhang TQ, and Wang JW*. (2023). Anisotropic cell growth at the leaf base promotes age-related changes in leaf shape in Arabidopsis thaliana. Plant Cell. 35(5): 1386-1407.

 

12. Wang FX, Shang GD, and Wang JW*. (2022). Towards a hierarchical gene regulatory network underlying somatic embryogenesis. Trends Plant Sci. 27(12): 1209-1217.

 

13. Gao J#, Zhang K#, Cheng YJ#, Shang GD, Wang FX, Wu LY, Xu ZG, Mai YX, Zhao XY, Zhai D, Lian H, and Wang JW*. (2022). A robust mechanism for reset of juvenility during each generation in Arabidopsis. Nat Plants. 8(3): 257-268.

 

14. Shang GD, Xu ZG, Wan MC, Wang FX, and Wang JW*. (2022). FindIT2: an R/Bioconductor package to identify influential transcription factor and targets based on multi-omics data. BMC Genomics. 23(Suppl 1): 272.

 

15. Wu LY#, Shang GD#, Wang FX, Gao J, Wan MC, Xu ZG, and Wang JW*. (2022). Dynamic chromatin state profiling reveals regulatory roles of auxin and cytokinin in shoot regeneration. Dev Cell. 57(4): 526-542.

 

16. Qin H#, Ou L#, Gao J, Chen L, Wang JW*, Hao P*, and Li X*. (2022). DENA: training an authentic neural network model using Nanopore sequencing data of Arabidopsis transcripts for detection and quantification of N6-methyladenosine on RNA. Genome Biol. 23(1): 25.


17. Huang K#, Wu XX#, Fang CL#, Xu ZG#, Zhang HW, Gao J, Zhou CM, You LL, Gu ZX, Mu WH, Feng Y*, Wang JW*, and Zhang Y*. (2021). Pol IV and RDR2: a two-RNA-polymerase machine that produces double-stranded RNA. Science. 374(6575): 1579-1586.

 

18. Tian ZX#, Wang JW#, Li J*, Han B*. (2021). Designing Future Crops: challenges and strategies for sustainable agriculture. Plant J. 105(5):1165-1178.

 

19. Wang FX#, Shang GD#, Wu LY, Mai YX, Gao J, Xu ZG, and Wang JW*. (2021). Protocol for assaying chromatin accessibility using ATAC-seq in plants. STAR Protocols. 2: 100289.

 

20. Cheng YJ, Shang GD, Xu ZG, Yu S, Wu LY, Zhai D, Tian SL, Gao J, Wang L, and Wang JW*. (2021). Cell division in the shoot apical meristem is a trigger for miR156 decline and vegetative phase transition in Arabidopsis. Proc Natl Acad Sci USA. 118(46): e2115667118.

 

21. Zhang TQ, Chen Y, Liu Y, and Wang JW*. (2021). Single-cell transcriptome atlas and chromatin accessibility landscape reveal differentiation trajectories in the rice root. Nat Commun. 12: 2053.

 

22. Zhang TQ, Chen Y, and Wang JW*. (2021). A single-cell analysis of the Arabidopsis vegetative shoot apex. Dev Cell. 56(7): 1056-1074.

 

23. Lian H, Wang L, Ma N, Zhou CM, Han L, Zhang TQ, and Wang JW*. (2021). Redundant and specific roles of individual MIR172 genes in plant development. PLoS Biol. 19(2): e3001044.

 

24. Yu S* and Wang JW*. (2020). The crosstalk between microRNAs and gibberellin signaling in plant. Plant Cell Physiol. 61(11): 1880-1890.

 

25. Ye BB, Zhang K, and Wang JW*. (2020). The role of miR156 in rejuvenation in Arabidopsis thaliana. J Integr Plant Biol. 62(5): 550-555.

 

26. Wang FX#, Shang GD#, Wu LY, Xu ZG, Zhao XY, and Wang JW*. (2020). Chromatin accessibility dynamics and a hierarchical structure of transcriptional regulatory network for plant somatic embryogenesis. Dev Cell. 54(6): 742-757.

 

27. Ye BB, Shang GD, Pan Y, Xu ZG, Zhou CM, Mao YB, Bao N, Sun L, Xu T, and Wang JW*. (2020). AP2/ERF transcription factors integrate age and wound signals for root regeneration. Plant Cell. 32(1): 226-241.

 

28. Wang L#, Zhou CM#, Mai YX, Li LZ, Gao J, Shang GD, Lian H, Han L, Zhang TQ, Tang HB, Ren H, Wang FX, Wu LY, Liu XL, Wang CS, Chen EW, Zhang XN, Liu C, and Wang JW*. (2019). A spatiotemporally regulated transcriptional complex underlies heteroblastic development of leaf hairs in Arabidopsis thaliana. EMBO J. 38(8): 100063.

 

29. Zhang TQ#, Xu ZG#, Shang GD, and Wang JW*. (2019). A single-cell RNA sequencing profiles the developmental landscape of Arabidopsis root. Mol Plant. 12(5): 648-660.

 

30. Zhang TQ, Lian H, Zhou CM, Xu L, Jiao YL, and Wang JW*. (2017). A two-step model for de novo activation of WUSCHEL during plant shoot regeneration. Plant Cell. 29(5): 1073-1087.

 

31. Wang L, and Wang JW*. (2015). Coding function for non-coding RNA in plants—insights from miRNA encoded peptide (miPEP). SCI CHINA Life Sci. 58(5): 503-505.

 

32. Yu S, Lian H, and Wang JW*. (2015). Plant developmental transitions: the role of microRNAs and sugars. Curr Opin Plant Biol. 27: 1-7.

 

33. Zhang TQ, Wang JW, and Zhou CM*. (2015). The role of miR156 in developmental transitions in Nicotiana tabacum. SCI CHINA Life Sci. 58(3): 253-260.

 

34. Zhang TQ, Lian H, Tang H, Dolezal K, Zhou CM, Yu S, Chen JH, Chen Q, Liu H, Ljung K, and Wang JW*. (2015). An intrinsic microRNA timer regulates progressive decline in shoot regenerative capacity in plants. Plant Cell. 27(2): 349-360.

 

35. Rubio-Somoza I, Zhou CM, Confraria A, Martinho C, Born P, Baena-Gonzalez E, Wang JW*, and Weigel D*. (2014). Temporal control of leaf complexity by miRNA-regulated licensing of protein complexes. Curr Biol. 24(22): 2714-2719.

 

36. Wang JW*. (2014). Regulation of flowering time by miR156-mediated age pathway. J Exp Bot. 65(17): 4723-4730.

 

37. Zhou CM and Wang JW*. (2013). Regulation of flowering time by microRNAs. J Genet Genomics. 40(5): 211-215.

 

38. Zhou CM, Zhang TQ, Wang X, Yu S, Lian H, Tang H, Feng ZY, Zozomova-Lihova J, and Wang JW*. (2013). Molecular basis of age-dependent vernalization in Cardamine flexuosa. Science. 340(6136): 1097-1100.

 

39. Yu S, Cao L, Zhou CM, Zhang TQ, Lian H, Sun Y, Wu JQ, Huang JR, Wang GD, and Wang JW*. (2013). Sugar is an endogenous cue for juvenile-to-adult phase transition in plants. eLife. 2: e00269.

 

40. Yu S#, Galvao V#, Zhang YC, Horrer D, Zhang TQ, Hao YH, Feng YQ, Wang S, Schmid M, and Wang JW*. (2012). Gibberellin regulates Arabidopsis floral transition through miR156-targeted SQUAMOSA PROMOTER BINDING-LIKE transcription factors. Plant Cell. 24(8): 3320-3332.

 

41. Gou JY, Felipes FF, Liu CJ, Weigel D, and Wang JW*. (2011). Negative Regulation of anthocyanin biosynthesis in Arabidopsis by a miR156-targeted SPL transcription factor. Plant Cell. 23(4): 1512-1522.

 

42. Wang JW*#, Park MY#, Wang LJ, Chen XY, Weigel D, and Poethig S*. (2011). MiRNA control of vegetative phase change in trees. PLoS Genet. 7: e1002012.