Principal Investigator, Academician of CAS
Researcher
Email:bhan@ncgr.ac.cn
Personal Web: http://www.ncgr.ac.cn

National Center for Gene Research,CAS

Education   

1989-1992  

Ph.D. in Molecular Genetics The Sainsbury Laboratory/John Innes Centre, Norwich, UK 

1985-1988  

M. Phil. in Molecular Genetics Guangxi Agricultural College, Nanning, Guangxi, China  

1981-1985 B.S. in Biology 

Department of Biology, Anhui Normal University, Wuhu, Anhui, China 

Professional Experienc  

1998-present 

Professor National Center for Gene Research, Chinese Academy of Sciences, China 

1993-1998 

Postdoctoral Associate Department of Plant Sciences, Cambridge University, Cambridge, UK 

2001-2005 

Principle Investigator and member International Rice Genome Sequencing Project (IRGSP)   

2001-present 

Director National Center for Gene Research, Chinese Academy of Sciences, China   

2014-present 

Director Shanghai Institute of Plant Physiology and Ecology, SIBS, CAS, China  

2014-present 

Vice-presidents Chinese Society of Genetics & Chinese Society of Plant Biology 

Prof. Han has been working on 1) genome sequencing and transcriptome studies, 2) sequencing-based genotyping and GWAS, 3) domestication studies, and 4) heterosis studies, using rice as crop of interest. 

He has achieved great success in all these fields. His lab has firstly finished rice chromosome 4 sequence. By using next-generation sequencing technology, he performed high-resolution genotyping, data imputation and whole genome sequencing-based GWA study, and succeeded to identify a substantial number of quantitative trait loci potentially important for rice production and improvement. Furthermore, by extending this technology into the construction of the rice genome-variation map, he unlocked the origin and domesticated process of Asian cultivated rice. The genetic mechanism of heterosis in crops has long been a puzzle despite the fact that heterosis had been discovered more than a century ago and that various genetic models have already been proposed to explain it. By using the same forward genetic and genomic approaches, Han’s group performed large-scale genomic mapping for yield-related traits and heterotic effects in thousands of hybrid rice varieties, and characterized the genomic architecture of heterosis for yield traits in rice, which succeeded to reveal the mechanism behind this biologically and agronomically important phenomenon. Very recently, his lab has demonstrated the extent of genomic variations among rice complex through a rice pan-genome study. These works are among the most notable epoch-making achievements in rice genome research since the elucidation of the whole genome sequence of rice, and he has actually published many papers dealing with these topics in top journals, including Nature, Nature Genetics, Nature Communications, Genome Research, and Plant Cell. 

1. Changsheng Wang, Shican Tang, Qilin Zhan, …., Jianfu Zhang, Huaan Xie, Xuehui Huang & Bin Han*. Dissecting a heterotic gene through GradedPool-Seq mapping informs a rice-improvement strategy. Nature Communicationsvolume 10, Article number: 2982 (2019) 

2. Junyi Gong, Jiashun Miao, Yan Zhao, Qiang Zhao, Qi Feng, Qilin Zhan, Benyi Cheng, Junhui Xia, Xuehui Huang4, Shihua Yang, and Bin Han*.Dissecting the Genetic Basis of Grain Shape and Chalkiness Traits in Hybrid Rice Using Multiple Collaborative Populations. Molecular Plant 2017; 10(10):1353-1356 

3. Xuehui Huang, Shihua Yang, Junyi Gong, Qiang Zhao, Qi Feng, Qilin Zhan, Yan Zhao, Wenjun Li, Benyi Cheng, Junhui Xia, Neng Chen, Tao Huang, Lei Zhang, Danlin Fan, Jiaying Chen, Congcong Zhou, Yiqi Lu, Qijun Weng & Bin Han*.Genomic architecture of heterosis for yield traits in rice. Nature 2016; doi:10.1038/nature19760. 

4. Huang XH, Yang SH, Gong JY, Zhao Y, Feng Q, Gong H, Li WJ, Zhan QL, Cheng BY, Xia JH, Chen N, Hao ZN, Liu HY, Zhu CR, Huang T, Zhao Q, Zhang L, Fan DL, Zhou CC, Lu YQ, Weng QJ, Wang Z-X, Li JY, Han, B* Genomic analysis of hybrid rice varieties reveals numerous superior alleles that contribute to heterosis. Molecular Plant 2015; DOI: http://dx.doi.org/10.1016/j.molp.2015.01.010. 

5. Huang X, Kurata N, Wei X, Wang Z-X, Wang A, Zhao Q, Zhao Y, Liu K, Lu H, Li W, Guo Y, Lu Y, Zhou C, Fan D, Weng Q, Zhu C, Huang T, Zhang L, Wang Y, Feng L, Furuumi H, Kubo T, Miyabayashi T, Yuan X, Xu Q, Dong G, Zhan Q, Li C, Fujiyama A, Toyoda A, Lu T, Feng Q, Qian Q, Li J, Han B*. A map of rice genome variation reveals the origin of cultivated rice. Nature 2012; 490: 497-501.  

6. Zhou, Y., Lu,D., Li, C., Luo, J., Zhu, B., Zhu, J., Shangguan, Y., Wang, Z., Sang, T., Zhou, B., & Han, B*. Genetic control of seed shattering in rice by the APETALA2 transcription factor SHATTERING ABORTION1. Plant Cell 2012, 24, 1034-1048.  

7. Huang, X., Zhao, Y., Wei, X., Li, C., Wang, A., Zhao, Q…., Huang, T., Lu, T., Feng, Q., Qian, Q., Li, J., & Han, B*. Genome-wide association study of flowering time and grain yield traits in a worldwide collection of rice germplasm. Nature Genet. 2012, 44, 32-39.  

8. Huang, X., Wei, X., Sang, T., Zhao, Q., Feng, Q., …., Li, W., Lin, Z., Buckler, E.S., Qian, Q., Zhang, Q., Li, J., & Han, B*. Genome-wide association studies of 14 agronomic traits in rice landraces. Nature Genet. 2010, 42, 961-967. 

9. International Rice Genome Sequencing Project. The map-based sequence of the rice genome. Nature 2005, 436, 793-800. (Bin Han is one of the 10 principal investigators of this joint paper). 

10. Feng, Q., Zhang, Y.J., …. Hong, G.F., Xue, Y.B. & Han, B*. Sequence and analysis of rice chromosome 4. Nature 2002, 420, 336-340.