Principal Investigator
Researcher
Email:jwwang@sibs.ac.cn
Personal Web: http://wanglab.sippe.ac.cn/

National Key Laboratory of Plant Molecular Genetics

Education  

1999-2005 

Ph D. in Plant Molecular Genetics Institute of Plant Physiology and Ecology Shanghai Institutes for Biological Sciences (SIBS) Chinese Academy of Sciences (CAS) 

1995-1999 

Bachelor of Philosophy in Life Science College of Life Sciences, Shanghai Jiaotong University 

Professional Experience  

2014- present  

Joint Professor Shanghai Tech University  

2011- present  

Principle investigator, Professor National Key Lab of Plant Molecular Genetics (NKLPMG) Institute of Plant Physiology and Ecology (SIPPE) CAS 

2005- 2011  

Postdoc Max Planck Institute for Developmental Biology, Department of Molecular Biology, Tuebingen, Germany 

Our work is based on the previous findings that miR156, one the most evolutionarily conserved plant microRNAs (miRNAs), is the key regulator for plant developmental timing. miR156 accumulates at a high level in seedlings and subsequently declines as plants age. This temporal expression pattern serves as an intrinsic timer for developmental transitions. Therefore, at individual level, dissection of the molecular mechanism by which miR156 senses plant age (the upstream events) and by which miR156 and its target SPL transcription factors regulate morphological and physiological changes (the downstream events) will help us to understand of the general principle underlying the irreversibility of life cycle in multicellular organisms. 

At the interspecies level, we are using Arabidopsis close relatives (eg. Cardamine and Arabis) as perennial models to understand how the life cycle strategy of higher plants is diversified and how the perennial-to-annual growth habit is evolved. 

1. Ye BB, Shang GD, Xu ZG, Mao YB, and Wang JW*. (2019). The Role of miR156 in Rejuvenation in Arabidopsis thaliana. J Integr Plant Biol. doi: 10.1111/jipb.12855. 

2. Zhang TQ^#, Xu ZG^#, Shang GD, and Wang JW*. (2019). A single-cell RNA sequencing profiles the developmental landscape of Arabidopsis root. Mol Plant. 12(5): 648-660. 

3. Wang L^#, Zhou CM^#, Mai YX, Li LZ, Gao J, Shang GD, Lian H, Han L, Zhang TQ, Tang HB, Ren H, Wang FX, Wu LY, Liu XL, Wang CS, Chen EW, Zhang XN, Liu C, and Wang JW*. (2019). A spatiotemporally regulated transcriptional complex underlies heteroblastic development of leaf hairs in Arabidopsis thaliana. EMBO J. 38(8): 100063. 

4. Zhang TQ, Lian H, Zhou CM, Xu L, Jiao YL, and Wang JW*. (2017). A Two-Step Model for de novo Activation of WUSCHEL during Plant Shoot Regeneration. Plant Cell. 29(5): 1073-1087. 

5. Wang J, Tian C, Zhang C, Shi B, Cao X, Zhang TQ, Zhao Z, Wang JW, and Jiao YL*. (2017). Cytokinin Signaling Activates WUSCHEL Expression during Axillary Meristem Initiation. Plant Cell. 29(6): 1373-1387. 

6. Wang J^#, Cheng YJ^#, Hu B, Ma X, Wang JW, and Liu C*. (2017). Non-random domain organization of the Arabidopsis genome at the nuclear periphery. Genome Res. 27(7): 1162-1173. 

7. Mao YB, Liu YQ, Chen DY, Chen FY, Fang X, Hong GJ, Wang LJ, Wang JW, and Chen XY*. (2017). Jasmonate response decay and defense metabolite accumulation contributes to age-regulated dynamics of plant insect resistance. Nat Commun. 8: 13925. 

8. Chen L, Tong J, Xiao L, Ruan Y, Liu J, Zeng M, Huang H, Wang JW, and Xu L*. (2016). YUCCA-mediated auxin biogenesis is required for cell fate transition occurring during de novo root organogenesis in Arabidopsis. J Exp Bot. 67: 4273-4284. 

9. Ma D, Hu Y, Yang C, Liu B, Fang L, Wan Q, Liang W, Mei G, Wang L, Wang H, Ding L, Dong C, Pan M, Chen J, Wang S, Chen S, Cai C, Zhu X, Guan X, Zhou B, Zhu S, Wang JW, Guo W, Chen XY, Zhang T*. (2016). Genetic basis for glandular trichome formation in cotton. Nat Commun. 7: 10456. 

10. Yu S, Lian H, and Wang JW*. (2015). Plant Developmental Transitions: the Role of MicroRNAs and Sugars. Curr Opin Plant Biol. 27: 1-7. (invited review) 

11. Wang L, and Wang JW*. (2015). Coding function for non-coding RNA in plants—insights from miRNA encoded peptide (miPEP). Sci China Life Sci. 58: 503-505.(Insight). 

12. Zhang TQ, Wang JW, and Zhou CM*. (2015). The role of miR156 in developmental transitions in Nicotiana tabacum. Sci China Life Sci. 58: 253-260. 

13. Zhang TQ, Lian H, Tang H, Dolezal K, Zhou CM, Yu S, Chen JH, Chen Q, Liu H, Ljung K, and Wang JW*. (2015). An Intrinsic MicroRNA Timer Regulates Progressive Decline in Shoot Regenerative Capacity in Plants. Plant Cell. 27(2): 349-360. 

14. Rubio-Somoza I, Zhou CM, Confraria A, Martinho C, Born P, Baena-Gonzalez E, Wang JW*, and Weigel D*. (2014). Temporal control of leaf complexity by miRNA-regulated licensing of protein complexes. Curr Biol. 24: 2714-2719. 

15. Wang JW*. (2014). Regulation of flowering time by miR156-mediated age pathway. J Exp Bot. 65: 4723-4730. 

16. Zhou CM, Zhang TQ, Wang X, Yu S, Lian H, Tang H, Feng ZY, Zozomova-Lihova J, and Wang JW*. (2013). Molecular Basis of Age-dependent Vernalization in Cardamine flexuosa. Science. 340: 1097-1100. 

17. Yu S, Cao L, Zhou CM, Zhang TQ, Lian H, Sun Y, Wu JQ, Huang JR, Wang GD, and Wang JW*. (2013). Sugar is an Endogenous Cue for Juvenile-to-Adult Phase Transition in Plants. eLife. 2: e00269. 

18. Zhou CM and Wang JW*. (2013). Regulation of Flowering Time by MicroRNAs. J Genet Genomics. 40: 211-215. 

19. Yu S^#, Galvao V^#, Zhang YC, Horrer D, Zhang TQ, Hao YH, Feng YQ, Wang S, Schmid M, and Wang JW*. (2012). Gibberellin Regulates Arabidopsis Floral Transition through miR156-Targeted SQUAMOSA PROMOTER BINDING-LIKE Transcription Factors. Plant Cell. 24(8): 3320-3332. 

20. Felipes FF, Wang JW, and Weigel D*. (2012). MIGS: miRNA induced gene silencing. Plant J. 70: 541-547. 

21. Gou JY, Felipes FF, Liu CJ, Weigel D, and Wang JW*. (2011). Negative Regulation of Anthocyanin Biosynthesis in Arabidopsis by a miR156-Targeted SPL Transcription Factor. Plant Cell. 23(4): 1512-1522. 

22. Wang JW*^#, Park MY^#, Wang LJ, Chen XY, Weigel D, and Poethig S*. (2011). MiRNA Control of Vegetative Phase Change in Trees. PLoS Genet. 7: e1002012. 

23. Laubinger S, Zeller G, Henz S, Buechel S, Sachsenberg T, Wang JW, R？tsch G, and Weigel D*. (2010). Global effects of the small RNA biogenesis machinery on the Arabidopsis thaliana transcriptome. PNAS. 107: 17466-17473. 

24. Wang JW, Czech B, Weigel D. (2009). miR156-regulated SPL transcription factors define an endogenous flowering pathway in Arabidopsis thaliana. Cell. 138: 738-749. 

25. Wu G, Park MY, Conway SR, Wang JW, Weigel D, Poethig S*. (2009). The sequential action of miR156 and miR172 regulates developmental timing in Arabidopsis. Cell. 138: 750-759. 

26. Wang JW, Schwab R, Czech B, Mica E, Weigel D*. (2008). Dual effects of miR156-Targeted SPL genes and CYP78A5/KLUH on plastochron length and organ size in Arabidopsis thaliana. Plant Cell. 20(5): 1231-1243. 

27. Mao YB, Cai WJ, Wang JW, Hong GJ, Tao XY, Wang LJ, Huang YP, Chen XY*. (2007). Silencing a cotton bollworm P450 monooxygenase gene by plant-mediated RNAi impairs larval tolerance of gossypol. Nat Biotechnol. 25: 1307-1313. 

28. Wang JW, Wang LJ, Mao, YB, Cai WJ, Xue HW, Chen XY*. (2005). Control of root cap development by microRNA-targeted auxin response factors in Arabidopsis. Plant Cell. 17: 2204-2216.