Personal Information

Principal Investigator, Academician of CAS
Researcher
Email:xychen@sibs.ac.cn
Personal Web: http://sippe.ac.cn/xy


Research Direction

 


Research Unit

National Key Laboratory of Plant Molecular Genetics

Xiaoya Chen

Personal Profile

Dr. Xiao-Ya Chen, Professor, CAS Center for Excellence in Molecular Plant Sciences/Institute of Plant Physiology and Ecology, Chinese Academy of Sciences.  

Elected member (Academician) of Chinese Academy of Sciences in 2005 and member of the Academy of Sciences for the Developing World (TWAS) in 2008. 

Education 

1982-1985, Ph.D., Reading University, UK 

1978-1982, B.S., Nanjing University, China 

Working Experience 

1994-Now, Principal Investigator, Professor, Institute of Plant Physiology and Ecology, SIBS, CAS 

1997.5-1997.10, Visiting professor, Nara Institute of Advanced Science and technology, Japan 

1992-1994, Postdoctoral fellow, Purdue University, USA  

1991-1992, Visiting scientist, Tübingen University, Germany 

1989-1991, Associate professor, Nanjing University, China 

1986-1988, Lecturer, Nanjing University, China 

Awards / Honors: 

1. 2017, First Prize of Shanghai Natural Science Award 

2. 2015, Shanghai Science Popular Education Innovation Award 

3. 2014, Outstanding Contribution to Cotton Genomics, the Third ICGI Award 

4. 2008, HLHL Foundation Prize for Scientific and Technological Progress 


Research Work

Research in my group includes plant specialized metabolism, plant-insect interactions and cotton fiber development. 

Plant specialized or secondary metabolism plays important roles in plant adaptation to environments, particularly in mediating bio-interactions and protecting plants from herbivores and pathogens. Some of the metabolites are highly valuable and used as medicines, food nutrients and in other industrial applications. 

Terpenoids form the largest group of plant secondary metabolites. We are interested in sesquiterpene biosynthesis and regulation. In addition to elucidate the gossypol biosynthetic pathway in cotton (Gossypium spp.) and plant defense against insect herbivores, we also investigate the terpenoid biosynthesis in Arabidopsis and selected medicinal plants, such as Salvia. 

We recently started our project on plant quinones, including in particular the biosynthetic pathway of ubiquinone, or Coenzyme Q (CoQ), in plants and use synthetic biology approaches to crop breeding for better nutrition. 

Cotton fiber, the seed trichome of cotton, is the most important natural fiber for textile industry and a good model to investigate cell elongation and cell wall biosynthesis. In this direction, we are particularly interested in identification of transcription factors and the regulatory complex that control cotton fiber elongation. 

Current projects include: 

(1) Gossypol biosynthesis pathway with emphasis on the novel aromatization mechanisms and distinct modifications; terpenoid biosynthesis in the selected medicinal plants; enzyme evolution and engineering; 

(2) Ubiquinone biosynthesis in plant and improvement of crop nutrition;  

(3) Plant-insect interactions, RNAi technology against insect pests; 

(4) Transcription factors and their complex controlling cotton fiber (trichome) development.  


Main Achievements

植物次生代谢物在植物与环境、尤其是抗病抗虫过程中发挥重要作用,许多成分具有重要的药用或其它应用价值。研究组对植物倍半萜、尤其是棉酚和青蒿素生物的合成途径及调控开展了系统深入的研究,克隆鉴定了棉酚合成途径一系列酶和调控因子基因,解析了植物激素和microRNA调控倍半萜生物合成的分子机制。通过研究棉铃虫与植物的相互作用,发展了植物介导的RNA干扰抗虫技术,率先研发新一代植物抗虫技术。研究棉纤维发育及调控机理,分离鉴定了关键调控因子和细胞壁蛋白基因,阐述了植物激素GA在纤维发育过程中调控下游转录因子的机制;发现miRNA靶基因调控表皮毛和棉纤维发育,结果对棉纤维品质改良具有重要意义。

在国内外发表论文150余篇,包括Nature Biotechnology, Nature Communications, Plant Cell等国际重要刊物,申请或授权专利20多项。曾获何梁何利科学技术进步奖,全国优秀博士学位论文指导教师奖,国际棉花基因组指导委员会(ICGI)杰出贡献奖,上海科普教育创新奖科普杰出人物奖,上海市自然科学奖一等奖等。目前承担国家基金委基础科学中心、基金委重大、国家科技重大、国家重点研发、中科院等科研项目。


Publications